Homo- and heptanor-sterols and tremulane sesquiterpenes from cultures of Phellinus igniarius.
Basic Information
ID: ALA1177748
Journal: J Nat Prod
Title: Homo- and heptanor-sterols and tremulane sesquiterpenes from cultures of Phellinus igniarius.
Authors: Wu X, Lin S, Zhu C, Yue Z, Yu Y, Zhao F, Liu B, Dai J, Shi J.
Abstract: Four steroids, a homopregnene (1) and three heptanorergosterane derivatives (2-4), nine tremulane sesquiterpenes (5-13), and 18 known compounds have been isolated from cultures of the fungus Phellinus igniarius. Their structures and absolute configurations were elucidated by spectroscopic data analysis. In preliminary in vitro assays, at 10(-5) M, compounds 8, 9, 13, and 3beta-hydroxy-11,12-O-isopropyldrimene (14) showed significant vascular-relaxing activities against phenylephrine-induced vasoconstriction with relaxing rates of 35.7%, 45.4%, 46.6%, and 32.1%, respectively, as compared with the blank control.
CiteXplore: 20583752
DOI: 10.1021/np100216k
Patent ID: ┄