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ID: ALA1177794
Journal: Bioorg Med Chem Lett
Title: Broad spectrum alkynyl inhibitors of T315I Bcr-Abl.
Authors: Deng X, Lim SM, Zhang J, Gray NS.
Abstract: A series of alkyne-containing type II inhibitors with potent inhibitory activity of T315I Bcr-Abl has been identified. The most active compound 4 exhibits an EC(50) of less than 1 nM against wild-type Bcr-Abl and an EC(50) of 10 nM against T315I mutant but is broadly active against a number of other kinases.
CiteXplore: 20541934