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ID: ALA1177801
Journal: Bioorg Med Chem Lett
Title: Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors.
Authors: Wallace MB, Adams ME, Kanouni T, Mol CD, Dougan DR, Feher VA, O'Connell SM, Shi L, Halkowycz P, Dong Q.
Abstract: A novel series of pyrrole inhibitors of MEK kinase has been developed using structure-based drug design. Optimization of the series led to the identification of potent inhibitors with good pharmaceutical properties.
CiteXplore: 20621728