Document Report Card
Basic Information
ID: ALA1177818
Journal: Bioorg Med Chem Lett
Title: Synthesis and biological evaluation of novel biotin-iminoalditol conjugates.
Authors: Pototschnig G, De Csáky CM, Burke JR, Schitter G, Stütz AE, Tarling CA, Withers SG, Wrodnigg TM.
Abstract: Biotin-iminosugar conjugates of different configuration such as D-gluco, D-galacto, L-ido as well as a furanoid representative in the D-manno configuration have been synthesised and exhibit powerful inhibition of beta-glucosidase from Agrobacterium sp. with K(i) values in the range of the respective parent compounds. Such molecular probes have potential for activity-based protein profiling taking advantage of the biotin-(strept)avidin interaction.
CiteXplore: 20610152