Document Report Card
Basic Information
ID: ALA1177821
Journal: Bioorg Med Chem Lett
Title: Structure-activity relationships and hepatic safety risks of thiazole agonists of the thrombopoietin receptor.
Authors: Antipas AS, Blumberg LC, Brissette WH, Brown MF, Casavant JM, Doty JL, Driscoll J, Harris TM, Jones CS, McCurdy SP, McElroy E, Mitton-Fry M, Munchhof MJ, Reim DA, Reiter LA, Ripp SL, Shavnya A, Smeets MI, Trevena KA.
Abstract: 5-F substitution of an aminothiazole moiety within a series of thrombopoietin receptor agonists leads to potent agents with an improved hepatic safety profile in rodent toxicology studies.
CiteXplore: 20558059