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ID: ALA1177856

Journal: Eur J Med Chem

Title: Synthesis and cytotoxic activity of fluorinated analogues of Goniothalamus lactones. Impact of fluorine on oxidative processes.

Authors: Dumitrescu L, Mai Huong DT, Van Hung N, Crousse B, Bonnet-Delpon D.

Abstract: Novel fluorinated analogues of goniothalamin 1 and howiinol A 2 have been prepared from trifluorocrotonate derivatives. Trifluoromethyl goniothalamin (R/S) 4 showed a slightly lower activity than 1, while the trifluoromethyl howiinol A 16 exhibited similar activities on several cell lines in the micromolar range. Unlike (R) goniothalamin and howiinol A, trifluoromethyl parent compounds remained unchanged when submitted to biomimetic oxidative systems.

CiteXplore: 20392543

DOI: 10.1016/j.ejmech.2010.03.032