Document Report Card
Basic Information
ID: ALA1208724
Journal: Bioorg Med Chem Lett
Title: A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase.
Authors: Gattinoni S, Simone CD, Dallavalle S, Fezza F, Nannei R, Battista N, Minetti P, Quattrociocchi G, Caprioli A, Borsini F, Cabri W, Penco S, Merlini L, Maccarrone M.
Abstract: A series of oxime carbamates have been identified as potent inhibitors of fatty acid amide hydrolase (FAAH), an important regulatory enzyme of the endocannabinoid signaling system. Kinetic analysis indicates that they behave as non-competitive, reversible inhibitors, and show remarkable selectivity for FAAH over the other components of the endocannabinoid system.
CiteXplore: 20591666