Document Report Card
Basic Information
ID: ALA1208743
Journal: Bioorg Med Chem Lett
Title: Discovery of novel sphingosine kinase-1 inhibitors. Part 2.
Authors: Xiang Y, Hirth B, Kane JL, Liao J, Noson KD, Yee C, Asmussen G, Fitzgerald M, Klaus C, Booker M.
Abstract: Building on our initial work, we have identified additional novel inhibitors of sphingosine kinase-1 (SK1). These new analogs address the shortcomings found in our previously reported compounds. Inhibitors 51 and 54 demonstrated oral bioavailability in a rat PK study.
CiteXplore: 20598880