Document Report Card

ID: ALA1212732

Journal: Nat Chem Biol

Title: Conformational inhibition of the hepatitis C virus internal ribosome entry site RNA.

Authors: Parsons J, Castaldi MP, Dutta S, Dibrov SM, Wyles DL, Hermann T.

Abstract: The internal ribosome entry site (IRES), a highly conserved structured element of the hepatitis C virus (HCV) genomic RNA, is an attractive target for antiviral drugs. Here we show that benzimidazole inhibitors of the HCV replicon act by conformational induction of a widened interhelical angle in the IRES subdomain IIa, which facilitates the undocking of subdomain IIb from the ribosome and ultimately leads to inhibition of IRES-driven translation in HCV-infected cells.

CiteXplore: 19767736

DOI: 10.1038/nchembio.217