Document Report Card

ID: ALA1212771

Journal: Antimicrob Agents Chemother

Title: BEL-2, an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa.

Authors: Poirel L, Docquier JD, De Luca F, Verlinde A, Ide L, Rossolini GM, Nordmann P.

Abstract: A Pseudomonas aeruginosa isolate recovered in Belgium produced a novel extended-spectrum ss-lactamase, BEL-2, differing from BEL-1 by a single Leu162Phe substitution. That modification significantly altered the kinetic properties of the enzyme, increasing its affinity for expanded-spectrum cephalosporins. The bla(BEL-2) gene was identified from a P. aeruginosa isolate clonally related to another bla(BEL-1)-positive isolate.

CiteXplore: 19884378

DOI: 10.1128/aac.00859-09