Document Report Card
Basic Information
ID: ALA1212879
Journal: Bioorg Med Chem
Title: Synthesis and T-type calcium channel blocking activity of novel diphenylpiperazine compounds, and evaluation of in vivo analgesic activity.
Authors: Kam YL, Rhee HK, Rhim H, Back SK, Na HS, Choo HY.
Abstract: Novel diphenylpiperazine derivatives were synthesized and evaluated for their inhibitory activity against T-type calcium channel by whole-cell patch clamp recordings on HEK293 cells. Among the test compounds, 2 and 3d were effective in decreasing the response to formalin in both the first and second phases and demonstrated antiallodynic effects in a rat model of neuropathic pain.
CiteXplore: 20659804