Document Report Card

ID: ALA1221175

Journal: Nat Chem Biol

Title: Purmorphamine activates the Hedgehog pathway by targeting Smoothened.

Authors: Sinha S, Chen JK.

Abstract: Hedgehog (Hh) signaling is an important regulator of embryonic patterning, tissue regeneration, stem cell renewal and cancer growth. A purine derivative named purmorphamine was previously found to activate the Hh pathway and affect osteoblast differentiation through an unknown mechanism. We demonstrate here that purmorphamine directly targets Smoothened, a critical component of the Hh signaling pathway.

CiteXplore: 16408088

DOI: 10.1038/nchembio753