Structure-activity studies on acetylcholinesterase inhibition in the lycorine series of Amaryllidaceae alkaloids.

ID: ALA1221246

Journal: Bioorg Med Chem Lett

Title: Structure-activity studies on acetylcholinesterase inhibition in the lycorine series of Amaryllidaceae alkaloids.

Authors: McNulty J, Nair JJ, Little JR, Brennan JD, Bastida J.

Abstract: The synthesis of differentially functionalized analogs of the Amaryllidaceae alkaloid lycorine, accessed via a concise chemoselective silylation strategy, is described uncovering two of the most potent inhibitors of acetylcholinesterase (AChE) identified to date in this series. Important elements of this novel pharmacophore were elucidated through structure-activity relationship (SAR) studies.

CiteXplore: 20655219

DOI: 10.1016/j.bmcl.2010.06.130

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