Synthesis of a series of novel 2,4,5-trisubstituted selenazole compounds as potential PLTP inhibitors.

Basic Information

ID: ALA1221268

Journal: Bioorg Med Chem Lett

Title: Synthesis of a series of novel 2,4,5-trisubstituted selenazole compounds as potential PLTP inhibitors.

Authors: Ling C, Zheng Z, Jiang XC, Zhong W, Li S.

Abstract: Based on a homology-modeled structure of PLTP and characteristic structural features of reported cholesteryl ester transfer protein (CETP) inhibitors, we designed and synthesized a novel series of 2,4,5-trisubstituted selenazole compounds. Biological evaluation reveals that compounds 12 and 17 exhibit favorable PLTP activity, and their IC(50)s are 8 microM and 10 microM, respectively.

CiteXplore: 20667734

DOI: 10.1016/j.bmcl.2010.07.017

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