Identification of a novel NR2B-selective NMDA receptor antagonist using a virtual screening approach.

ID: ALA1221329

Journal: Bioorg Med Chem Lett

Title: Identification of a novel NR2B-selective NMDA receptor antagonist using a virtual screening approach.

Authors: Mony L, Triballeau N, Paoletti P, Acher FC, Bertrand HO.

Abstract: We report the identification of a novel NR2B-selective NMDAR antagonist with an original scaffold, LSP10-0500. This compound was identified by a virtual high-throughput screening approach on the basis of a quantitative pharmacophore model of NR2B-specific NMDAR antagonists. A SAR study around LSP10-0500 is also described.

CiteXplore: 20692832

DOI: 10.1016/j.bmcl.2010.07.043

Patent ID: ┄