Caelestines A-D, brominated quinolinecarboxylic acids from the Australian ascidian Aplidium caelestis.
Basic Information
ID: ALA1221343
Journal: J Nat Prod
Title: Caelestines A-D, brominated quinolinecarboxylic acids from the Australian ascidian Aplidium caelestis.
Authors: Yin S, Boyle GM, Carroll AR, Kotiw M, Dearnaley J, Quinn RJ, Davis RA.
Abstract: Four new brominated natural products, caelestines A-D (1-4), have been isolated from the Australian ascidian Aplidium caelestis. The structures of 1-4 were determined by analysis of their NMR and MS data. This is the first report of brominated quinolinecarboxylic acids from nature. Compound 1 has been previously synthesized but not spectroscopically characterized. Compounds 1-4 were tested against three mammalian cell lines (MCF-7, NFF, and MM96L) and a panel of microbial strains and showed only minor cytotoxicity.
CiteXplore: 20704301
DOI: 10.1021/np100329w
Patent ID: ┄