Document Report Card

ID: ALA1240322

Journal: Nat Chem Biol

Title: Small-molecule regulation of zebrafish gene expression.

Authors: Esengil H, Chang V, Mich JK, Chen JK.

Abstract: The zebrafish has emerged as a versatile model organism for biomedical research, yet its potential has been limited by a lack of conditional reverse-genetic tools. Here we report a chemically inducible gene expression technology that has orthogonality to vertebrate signaling processes, high induction levels, and rapid kinetics. Coupled with tissue-specific promoters, this system provides multidimensional control of gene expression and will enable new models of human disorders and diseases.

CiteXplore: 17237798

DOI: 10.1038/nchembio858