Document Report Card

ID: ALA1240359

Journal: Antimicrob Agents Chemother

Title: Micafungin concentrations from brain tissue and pancreatic pseudocyst fluid.

Authors: Lat A, Thompson GR, Rinaldi MG, Dorsey SA, Pennick G, Lewis JS.

Abstract: We report the attainment of micafungin concentrations from brain tissue and pancreatic pseudocyst fluid from two patients with invasive candidiasis. Micafungin was present in low levels at both body sites, indicating limited penetration into central nervous system (CNS) tissue and pancreatic fluid. Further studies are needed to fully characterize its pharmacokinetics at these locations, as micafungin may potentially serve as an alternative antifungal therapy for CNS or pancreatic candidal infections for which the currently recommended first-line therapy fails.

CiteXplore: 19933794

DOI: 10.1128/aac.01294-09