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ID: ALA1240421
Journal: Eur J Med Chem
Title: Synthesis and evaluation of graveoline and graveolinine derivatives with potent anti-angiogenesis activities.
Authors: An ZY, Yan YY, Peng D, Ou TM, Tan JH, Huang SL, An LK, Gu LQ, Huang ZS.
Abstract: A series of graveoline and graveolinine derivatives were synthesized. The biological results showed that most of graveoline derivatives possessed higher cytotoxicity and better inhibitive effect against the adhesion and migration of human umbilical vein endothelial cell (HUVEC) than graveolinine derivatives. Among these compounds, 8d was the most potent agents that also showed significant anti-angiogenesis activities in chick embryo chorioallantoic membrane (CAM) assay.
CiteXplore: 20554355