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ID: ALA1240468
Journal: Eur J Med Chem
Title: Regioselective hydrostannation of diarylalkynes directed by a labile ortho bromine atom: an easy access to stereodefined triarylolefins, hybrids of combretastatin A-4 and isocombretastatin A-4.
Authors: Rasolofonjatovo E, Provot O, Hamze A, Bignon J, Thoret S, Brion JD, Alami M.
Abstract: A series of triarylolefins bearing the combretastatin A-4 and the isocombretastatin A-4 cores were synthesized and evaluated. The cooperative ortho-effect of a labile bromine atom in the regioselective hydrostannation of unsymmetrical diarylalkynes leading to stereodefined triarylolefins is presented.
CiteXplore: 20627378