Synthesis and biological evaluation of diastereoisomerically pure N,O-nucleosides.

ID: ALA1250537

Journal: Bioorg Med Chem

Title: Synthesis and biological evaluation of diastereoisomerically pure N,O-nucleosides.

Authors: Bortolini O, De Nino A, Eliseo T, Gavioli R, Maiuolo L, Russo B, Sforza F.

Abstract: Several N,O-nucleosides have been synthesized in good yields by direct 1,3-dipolar cyclization methodology, in the absence of solvent. A remarkable cis stereoselectivity (de 98%) was observed by tuning the substituents on the nitrone moiety. A good number of these N,O-nucleosides have been evaluated for cytotoxic activity against selected cellular lines. Some of the tested compounds have proven to be potential antiproliferative drugs.

CiteXplore: 20813537

DOI: 10.1016/j.bmc.2010.08.024

Patent ID: ┄