Document Report Card

ID: ALA1255235

Journal: Antimicrob Agents Chemother

Title: Molecular basis for resistance of acanthamoeba tubulins to all major classes of antitubulin compounds.

Authors: Henriquez FL, Ingram PR, Muench SP, Rice DW, Roberts CW.

Abstract: Tubulin is essential to eukaryotic cells and is targeted by several antineoplastics, herbicides, and antimicrobials. We demonstrate that Acanthamoeba spp. are resistant to five antimicrotubule compounds, unlike any other eukaryote studied so far. Resistance correlates with critical amino acid differences within the inhibitor binding sites of the tubulin heterodimers.

CiteXplore: 18070965

DOI: 10.1128/aac.00355-07