Pyrazinamide resistance and pncA gene mutations in Mycobacterium tuberculosis.

ID: ALA1255334

Journal: Antimicrob Agents Chemother

Title: Pyrazinamide resistance and pncA gene mutations in Mycobacterium tuberculosis.

Authors: Juréen P, Werngren J, Toro JC, Hoffner S.

Abstract: Thirty-four pyrazinamide-resistant and 37 pyrazinamide-susceptible Mycobacterium tuberculosis complex strains were analyzed for pncA gene mutations. None of the sensitive strains had any mutations, apart from silent mutations, whereas all but one resistant strain showed pncA mutations. By using sequencing as a means of early resistance detection, the inconsistency of phenotypic pyrazinamide assays can be circumvented.

CiteXplore: 18316515

DOI: 10.1128/aac.00110-08

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