Document Report Card

ID: ALA1255373

Journal: Antimicrob Agents Chemother

Title: In vitro antibacterial activity of CE-156811, a novel analog derived from hygromycin A.

Authors: Stone GG, Girard D, Finegan S, Duignan J, Schafer J, Maloney M, Zaniewski RP, Brickner SJ, Wade SK, Le PT, Huband MD.

Abstract: We evaluated a novel truncated hygromycin A analog in which the furanose ring was replaced with a 2-fluoro-2-cyclopropylethyl substituent for its activity against multidrug resistant gram-positive bacteria and compared its activity to the activities of linezolid, quinupristin-dalfopristin, and vancomycin. CE-156811 demonstrated robust in vitro activity against gram-positive bacteria that was comparable to that of linezolid.

CiteXplore: 18426902

DOI: 10.1128/aac.01326-07