Document Report Card

ID: ALA1255409

Journal: Antimicrob Agents Chemother

Title: In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria.

Authors: Citron DM, Tyrrell KL, Merriam CV, Goldstein EJ.

Abstract: The in vitro activities of ceftaroline, a novel, parenteral, broad-spectrum cephalosporin, and four comparator antimicrobials were determined against anaerobic bacteria. Against Gram-positive strains, the activity of ceftaroline was similar to that of amoxicillin-clavulanate and four to eight times greater than that of ceftriaxone. Against Gram-negative organisms, ceftaroline showed good activity against beta-lactamase-negative strains but not against the members of the Bacteroides fragilis group. Ceftaroline showed potent activity against a broad spectrum of anaerobes encountered in respiratory, skin, and soft tissue infections.

CiteXplore: 20100877

DOI: 10.1128/aac.01788-09