Discovery of a class of calcium sensing receptor positive allosteric modulators; 1-(benzothiazol-2-yl)-1-phenylethanols.
Basic Information
ID: ALA1255510
Journal: Bioorg Med Chem Lett
Title: Discovery of a class of calcium sensing receptor positive allosteric modulators; 1-(benzothiazol-2-yl)-1-phenylethanols.
Authors: Gustafsson M, Jensen J, Bertozzi SM, Currier EA, Ma JN, Burstein ES, Olsson R.
Abstract: 1-(Benzothiazol-2-yl)-1-(4-chlorophenyl)ethanol (1) was identified as a positive allosteric modulator (PAM) of the CaSR in a functional cell-based assay. This compound belongs to a class of compounds that is structurally distinct from other known positive allosteric modulators, for example, the phenylalkylamines cinacalcet, a modified analog (13) potently suppressed parathyroid hormone (PTH) release in rats, consistent with its profile as a PAM of CaSRs.
CiteXplore: 20727747
DOI: 10.1016/j.bmcl.2010.07.077
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