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ID: ALA1255540

Journal: Bioorg Med Chem Lett

Title: Synthesis and biological evaluation of novel coumarin-based inhibitors of Cdc25 phosphatases.

Authors: Valente S, Bana E, Viry E, Bagrel D, Kirsch G.

Abstract: The cell division cycle 25 (Cdc25) family of proteins are dual specificity phosphatases that activate cyclin-dependent kinase (CDK) complexes, which in turn regulate progression through the cell division cycle. Overexpression of Cdc25 proteins has been reported in a wide variety of cancers; their inhibition may thus represent a novel approach for the development of anticancer therapeutics. Herein we report new coumarin-based scaffolds endowed with a selective inhibition against Cdc25A and Cdc25C, being 6a and 6d the most efficient inhibitors and worthy of further investigation as anticancer agents.

CiteXplore: 20800482

DOI: 10.1016/j.bmcl.2010.07.130