Document Report Card
Basic Information
ID: ALA1255541
Journal: Bioorg Med Chem Lett
Title: Novel indoline-1- or 3,4-dihydroquinoline-1(2H)-substituted carbothiohydrazides as TPO receptor agonists.
Authors: Tang PC, Lu HJ, Chen YQ, Zheng H, Song P, Wang L, Qin Q, Gong AS.
Abstract: Synthesis and evaluation of novel series of indoline-1- or 3,4-dihydroquinoline-1(2H)-substituted carbothiohydrazide or carbohydrazide based small molecule compounds as thrombopoietin (TPO) receptor agonists are reported. Members of these compounds have been identified as full agonists of human c-mpl in BaF3/TPOR cell line. Indoline-1-carbohydrazide 9b exhibited reasonable pharmacokinetic profile.
CiteXplore: 20800483