9-Dihydroerythromycins as non-antibiotic motilin receptor agonists.
Basic Information
ID: ALA1255554
Journal: Bioorg Med Chem Lett
Title: 9-Dihydroerythromycins as non-antibiotic motilin receptor agonists.
Authors: Liu Y, Li Y, Chen Y, Zheng H, Claypool M, Myles DC, Carreras CW.
Abstract: A series of 9-dihydroerythromycin A and B analogues with modification of the desosamine nitrogen have been synthesized and screened for motilin agonist activity, antibiotic activity, tachyphylaxis and hERG channel current inhibition. Small alkyl groups resulted in the potency while compounds with a primary or secondary amine resulted in the low motilin agonist potency. Several compounds were identified as non-antibiotic motilin receptor agonists with minimal tachyphylaxis and low hERG interaction.
CiteXplore: 20801039
DOI: 10.1016/j.bmcl.2010.08.030
Patent ID: ┄