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ID: ALA1268894
Journal: Bioorg Med Chem Lett
Title: Synthesis and biological evaluation of novel hygromycin A antibacterial agents.
Authors: Visser MS, Freeman-Cook KD, Brickner SJ, Brighty KE, Le PT, Wade SK, Monahan R, Martinelli GJ, Blair KT, Moore DE.
Abstract: Novel hygromycin A derivatives bearing a variety of functionalized aminocyclitol moieties have been synthesized in an effort to increase the antibacterial activity and drug-like properties of this class of agents. A systematic study of the effect of alkylation and removal of the hydroxyls of the aminocyclitol directed us to a series of alkylated aminocyclitol derivatives with improved gram-positive activity.
CiteXplore: 20864341