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ID: ALA1268956

Journal: Bioorg Med Chem Lett

Title: 3-Urea-1-(phenylmethyl)-pyridones as novel, potent, and selective EP3 receptor antagonists.

Authors: Li YH, Tseng PS, Evans KA, Jaworski JP, Morrow DM, Fries HE, Wu CW, Edwards RM, Jin J.

Abstract: A series of 3-urea-1-(phenylmethyl)-pyridones was discovered as novel EP(3) antagonists via high-throughput screening and subsequent optimization. The synthesis, structure-activity relationships, and optimization of the initial hit that resulted in potent and selective EP(3) receptor antagonists such as 11g are described.

CiteXplore: 20926294

DOI: 10.1016/j.bmcl.2010.08.137