2-Aryl benzimidazoles: human SCD1-specific stearoyl coenzyme-A desaturase inhibitors.

ID: ALA1268980

Journal: Bioorg Med Chem Lett

Title: 2-Aryl benzimidazoles: human SCD1-specific stearoyl coenzyme-A desaturase inhibitors.

Authors: Powell DA, Ramtohul Y, Lebrun ME, Oballa R, Bhat S, Falgueyret JP, Guiral S, Huang Z, Skorey K, Tawa P, Zhang L.

Abstract: A series of potent, benzimidazole-based SCD inhibitors which demonstrate selectivity for the hSCD1 enzyme over the hSCD5 isoform are described. The compounds possess suitable cellular activity and pharmacokinetic properties which render them capable of inhibiting liver SCD activity in a mouse pharmacodynamic assay. These 2-aryl benzimidazoles may serve as valuable tools for studying selective hSCD1-inhibition.

CiteXplore: 20933412

DOI: 10.1016/j.bmcl.2010.09.094

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