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ID: ALA1269000
Journal: Bioorg Med Chem Lett
Title: Synthesis and biological evaluation of [D-lysine]8cyclosporin A analogs as potential anti-HCV agents.
Authors: Scribner A, Houck D, Huang Z, Mosier S, Peel M, Scorneaux B.
Abstract: An efficient synthesis of [D-lysine](8)cyclosporin A has been developed. Several analogs of [D-lysine](8)cyclosporin A have been synthesized and show promising anti-HCV activity, particularly compounds 39 and 43, which each exhibit an anti-HCV EC(50)<200 nM, and are each ≥50-fold less immunosuppressive than cyclosporin A.
CiteXplore: 20943390