Document Report Card

ID: ALA1275442

Journal: Antimicrob Agents Chemother

Title: Pharmacokinetics and tissue distribution of anidulafungin in rats.

Authors: Damle B, Stogniew M, Dowell J.

Abstract: This study assessed the tissue distribution of anidulafungin in rats. Anidulafungin rapidly distributed into tissues, achieving peak concentrations within 30 min, and maintained levels above MICs for common pathogens over 72 h. In tissues susceptible to fungal infection (liver, lung, spleen, kidney), exposure was 9- to 12-fold higher than in plasma.

CiteXplore: 18443124

DOI: 10.1128/aac.01596-07