Posaconazole enhances the activity of amphotericin B against hyphae of zygomycetes in vitro.

Basic Information

ID: ALA1275450

Journal: Antimicrob Agents Chemother

Title: Posaconazole enhances the activity of amphotericin B against hyphae of zygomycetes in vitro.

Authors: Perkhofer S, Locher M, Cuenca-Estrella M, Rüchel R, Würzner R, Dierich MP, Lass-Flörl C.

Abstract: The in vitro activity of posaconazole plus amphotericin B against conidia and hyphae of 30 clinical zygomycetes was investigated. The combination of posaconazole with amphotericin B was found to be significantly more synergistic (40%) against hyphae (P < 0.05) than against conidia (10%). Antagonism was not observed.

CiteXplore: 18458135

DOI: 10.1128/aac.00492-08

Patent ID: