Document Report Card

ID: ALA1275486

Journal: Antimicrob Agents Chemother

Title: Kinetic characterization of VIM-7, a divergent member of the VIM metallo-beta-lactamase family.

Authors: Samuelsen Ø, Castanheira M, Walsh TR, Spencer J.

Abstract: Purified recombinant VIM-7 possesses efficient penicillinase and carbapenemase activities comparable to those of VIM-2. Cephalosporinase activity was variable and generally lower than those of VIM-1 and VIM-2. A homology model suggests that the VIM-7 Tyr-218 Phe substitution may be responsible for the reduced catalytic efficiency against certain cephalosporins, including ceftazidime and cefepime.

CiteXplore: 18559652

DOI: 10.1128/aac.00166-08