Document Report Card

ID: ALA1275558

Journal: Antimicrob Agents Chemother

Title: Inhibition of Toxoplasma gondii by indirubin and tryptanthrin analogs.

Authors: Krivogorsky B, Grundt P, Yolken R, Jones-Brando L.

Abstract: New drugs are needed for treatment of Toxoplasma gondii infections. We tested derivatives of principles found in Isatis indigotica for in vitro efficacy against T. gondii infection. Indirubin-3'-oxime analogs showed modest micromolar activity, while tryptanthrin derivatives displayed 50% inhibitory doses in the low nanomolar range. Tryptanthrins have potential as anti-Toxoplasma infection therapeutics.

CiteXplore: 18824607

DOI: 10.1128/aac.00903-08