Synthesis, characterization and anti-microbial studies of some novel 2,4-disubstituted thiazoles.
Basic Information
ID: ALA1287641
Journal: Eur J Med Chem
Title: Synthesis, characterization and anti-microbial studies of some novel 2,4-disubstituted thiazoles.
Authors: Vijesh AM, Isloor AM, Prabhu V, Ahmad S, Malladi S.
Abstract: In the present study a series of novel 2,4-disubstituted thiazole derivatives containing substituted pyrazole moiety was synthesized by the reaction of 3-Aryl-1H-pyrazole-4-carbaldehyde thiosemicarbazone with 6-Bromo/H-3-(bromoacetyl)-2H-chromen-2-one/phenacyl chloride. Structures of newly synthesized compounds were characterized by spectral studies. New compounds were screened for their antibacterial studies against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa. The results revealed that compounds 7c, 8e, and 8f having 2,5-dichlorothiophene substituent and 8c, 8d having 2,4-dichlorophenyl substituent showed significant antibacterial activity against all tested microorganisms.
CiteXplore: 20716467
DOI: 10.1016/j.ejmech.2010.07.048
Patent ID: ┄