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ID: ALA1287692
Journal: Bioorg Med Chem Lett
Title: Structure-based design, synthesis and A-site rRNA co-crystal complexes of novel amphiphilic aminoglycoside antibiotics with new binding modes: a synergistic hydrophobic effect against resistant bacteria.
Authors: Hanessian S, Pachamuthu K, Szychowski J, Giguère A, Swayze EE, Migawa MT, François B, Kondo J, Westhof E.
Abstract: Incorporation of an hydrophobic (phenethylamino)ethyl ether at C2″ of N1-(HABA)-3',4'-dideoxyparomomycin led to a novel analog with an excellent antibacterial profile against a host of resistant bacteria.
CiteXplore: 20970332