Synthesis, biological evaluation and radiolabelling by 18F-fluoroarylation of a dopamine D3-selective ligand as prospective imaging probe for PET.

Basic Information

ID: ALA1287708

Journal: Bioorg Med Chem Lett

Title: Synthesis, biological evaluation and radiolabelling by 18F-fluoroarylation of a dopamine D3-selective ligand as prospective imaging probe for PET.

Authors: Höfling SB, Maschauer S, Hübner H, Gmeiner P, Wester HJ, Prante O, Heinrich MR.

Abstract: Radical (18)F-fluoroarylation with fluorine-18-labelled arenediazonium chlorides has been successfully applied to the radiochemical synthesis of the dopamine D(3)-selective ligand SH 317 ([(18)F]8). SH 317 has been evaluated as a new PET ligand candidate by in vivo experiments.

CiteXplore: 21030255

DOI: 10.1016/j.bmcl.2010.09.142

Patent ID: