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ID: ALA1287712
Journal: Bioorg Med Chem Lett
Title: Synthetic analogs of indole-containing natural products as inhibitors of sortase A and isocitrate lyase.
Authors: Lee YJ, Han YR, Park W, Nam SH, Oh KB, Lee HS.
Abstract: Guided by the inhibitory activities of indole-containing natural products against isocitrate lyase (ICL) from Candida albicans and sortase A (SrtA) from Staphylococcus aureus, a series of compounds structurally analogous to natural products were synthesized. Eight SrtA inhibitors and an ICL inhibitor having higher activities than the natural products were discovered by screening the enzyme inhibitory activities of synthesized compounds. Among the SrtA inhibitors discovered, six exhibited higher activities than p-hydroxymercuribenzoic acid, which suggests that these compounds have great potential as alternative antibacterial agents.
CiteXplore: 21035332