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ID: ALA1287779

Journal: Bioorg Med Chem Lett

Title: Indium(III) chloride catalyzed three-component coupling reaction: a novel synthesis of 2-substituted aryl(indolyl)kojic acid derivatives as potent antifungal and antibacterial agents.

Authors: Reddy BV, Reddy MR, Madan Ch, Kumar KP, Rao MS.

Abstract: Three-component coupling of aldehyde, indole and kojic acid has been achieved using a catalytic amount of InCl(3) under solvent free conditions to produce a novel series of 2-substituted aryl(indolyl)kojic acid derivatives in good yields and with high selectivity. These compounds are found to exhibit potent antifungal properties.

CiteXplore: 21067928

DOI: 10.1016/j.bmcl.2010.10.003