The identification of a series of novel, soluble non-peptidic neuropeptide Y Y2 receptor antagonists.

ID: ALA1287792

Journal: Bioorg Med Chem Lett

Title: The identification of a series of novel, soluble non-peptidic neuropeptide Y Y2 receptor antagonists.

Authors: Lunniss GE, Barnes AA, Barton N, Biagetti M, Bianchi F, Blowers SM, Caberlotto LL, Emmons A, Holmes IP, Montanari D, Norris R, Puckey GV, Walters DJ, Watson SP, Willis J.

Abstract: The identification and subsequent optimisation of a selective non-peptidic NPY Y2 antagonist series is described. This led to the development of amine 2, a selective, soluble NPY Y2 receptor antagonist with enhanced CNS exposure.

CiteXplore: 21074426

DOI: 10.1016/j.bmcl.2010.10.065

Patent ID: ┄