3,5-disubstituted pyranone analogues of highly antifungally active furanones: conversion of biological effect from antifungal to cytostatic.
Basic Information
ID: ALA1287798
Journal: Bioorg Med Chem Lett
Title: 3,5-disubstituted pyranone analogues of highly antifungally active furanones: conversion of biological effect from antifungal to cytostatic.
Authors: Schiller R, Tichotová L, Pavlík J, Buchta V, Melichar B, Votruba I, Kunes J, Spulák M, Pour M.
Abstract: A series of 3-aryl-5-acyloxymethyl-5,6-dihydro-2H-pyran-2-ones, related to highly antifungally active butenolides, was synthesized via cyclization of substituted δ-hydroxy acids as the key step, and evaluated for their in vitro antifungal activity and cytostatic activity. While the extension of the furanone ring to pyranone led to a complete loss of the antifungal effect, some of the compounds displayed promising effect against several cell lines, including the resistant colorectal carcinoma cells.
CiteXplore: 21074433
DOI: 10.1016/j.bmcl.2010.10.052
Patent ID: ┄