Second generation analogs of rigid 6,7-spiro scaffolds targeting the bacterial ribosome.
Basic Information
ID: ALA1629423
Journal: Bioorg Med Chem Lett
Title: Second generation analogs of rigid 6,7-spiro scaffolds targeting the bacterial ribosome.
Authors: Stathakis CI, Mavridis I, Kythreoti G, Papakyriakou A, Katsoulis IA, Cottin T, Anastasopoulou P, Vourloumis D.
Abstract: Previous work from our group described the synthesis and biological evaluation of new rigid, 6,6- and 6,7-spiro aminoglycosidic scaffolds targeting the bacterial ribosome. Herein we describe an improved synthetic protocol for their construction, and extend our study by further amino-functionalization of their 6,7-spiro analogs. The synthetic strategy, preparation and evaluation of some representative examples are reported.
CiteXplore: 21041083
DOI: 10.1016/j.bmcl.2010.10.001
Patent ID: ┄