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ID: ALA1629466
Journal: Eur J Med Chem
Title: Synthesis and biological activity of some antitumor active derivatives from glycyrrhetinic acid.
Authors: Csuk R, Schwarz S, Kluge R, Ströhl D.
Abstract: Aminoalkyl substituted derivatives were synthesized starting from glycyrrhetinic acid methyl ester and screened for antitumor activity in a panel of 15 human cancer cell lines by an SRB assay. The most compound 7 possesses an aminohexyl side chain, induces apoptosis and shows IC50 values of 0.6-3.0 μM.
CiteXplore: 20884085