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ID: ALA1629471
Journal: Eur J Med Chem
Title: Synthesis of (S)-(+)-decursin and its analogues as potent inhibitors of melanin formation in B16 murine melanoma cells.
Authors: Lee K, Lee JH, Boovanahalli SK, Choi Y, Choo SJ, Yoo ID, Kim DH, Yun MY, Lee GW, Song GY.
Abstract: We report the synthesis of a novel series of highly potent melanin inhibitors which were obtained through structural modification of an anticancer compound S-(+)-decursinol. The in vitro inhibitory potencies of the newly synthesized compounds were evaluated against α-MSH induced melanin production in B16 murine melanoma cells. Among the compounds evaluated, compounds 2, 3, 6b, 7a, 7b, 8a and 8b emerged as highly potent inhibitors of melanin production. Besides, these compounds demonstrated significantly low cytotoxicity.
CiteXplore: 20884093