Document Report Card

ID: ALA1629610

Journal: Antimicrob Agents Chemother

Title: A 6-aminoquinolone compound, WC5, with potent and selective anti-human cytomegalovirus activity.

Authors: Mercorelli B, Muratore G, Sinigalia E, Tabarrini O, Biasolo MA, Cecchetti V, Palù G, Loregian A.

Abstract: We identified a 6-aminoquinolone compound, WC5, that inhibits human cytomegalovirus (HCMV) replication with a selectivity index of approximately 500. WC5 also showed activity against drug-resistant HCMV strains. In contrast, it did not significantly affect the replication of human herpesvirus 6 and 8 and was approximately 10-fold less active against murine cytomegalovirus. Thus, WC5 may represent a lead for the development of new, potent, and selective anti-HCMV compounds.

CiteXplore: 19015358

DOI: 10.1128/aac.00988-08