Naphthalimide based novel organoselenocyanates: finding less toxic forms of selenium that would retain protective efficacy.

ID: ALA1629707

Journal: Bioorg Med Chem Lett

Title: Naphthalimide based novel organoselenocyanates: finding less toxic forms of selenium that would retain protective efficacy.

Authors: Roy SS, Ghosh P, Sk UH, Chakraborty P, Biswas J, Mandal S, Bhattacharjee A, Bhattacharya S.

Abstract: A series of naphthalimide based organoselenocyanates were synthesized and screened for their toxicity as well as their ability to modulate several detoxifying/antioxidative enzyme levels at a primary screening dose of 3 mg/kg b.w. in normal Swiss albino mice for 30 days. Compound 4d showed highest activity in elevating the detoxifying/antioxidant enzymes levels.

CiteXplore: 20971640

DOI: 10.1016/j.bmcl.2010.09.127

Patent ID: ┄