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ID: ALA1641418

Journal: Bioorg Med Chem Lett

Title: Discovery of isoindoline and tetrahydroisoquinoline derivatives as potent, selective PPARδ agonists.

Authors: Luckhurst CA, Stein LA, Furber M, Webb N, Ratcliffe MJ, Allenby G, Botterell S, Tomlinson W, Martin B, Walding A.

Abstract: Small molecule isoindoline and tetrahydroisoquinoline derivatives have been identified as selective agonists of human peroxisome proliferator-activated receptor δ (PPARδ. Compound 18 demonstrated efficacy in a biomarker for increased fatty acid oxidation, with upregulation of pyruvate dehydrogenase kinase, isozyme 4 (PDK4) in human primary myotubes.

CiteXplore: 21094606

DOI: 10.1016/j.bmcl.2010.10.117